Author Spang, Rainer

• 2021 | Journal Article | Research Paper
  ​ ​Identification of a miRNA based model to detect prognostic subgroups in patients with aggressive B-cell lymphoma​
  Nordmo, C.; Glehr, G.; Altenbuchinger, M. ; Spang, R.; Ziepert, M.; Horn, H. & Staiger, A. M. et al.​ (2021) 
  Leukemia & Lymphoma, 62(5) pp. 1107​-1115​.​ DOI: https://doi.org/10.1080/10428194.2020.1861268 
  ​Details  DOI  PMID  PMC 

• 2020 | Journal Article | 
  ​ ​High CD206 levels in Hodgkin lymphoma‐educated macrophages are linked to matrix‐remodeling and lymphoma dissemination​
  Arlt, A. ; Bonin, F. ; Rehberg, T.; Perez‐Rubio, P.; Engelmann, J. C.; Limm, K. & Reinke, S. et al.​ (2020) 
  Molecular Oncology, 14(3) pp. 571​-589​.​ DOI: https://doi.org/10.1002/1878-0261.12616 
  ​Details  DOI 

• 2020 | Journal Article | Research Paper
  ​ ​DTD: An R Package for Digital Tissue Deconvolution​
  Schön, M.; Simeth, J.; Heinrich, P.; Görtler, F.; Solbrig, S.; Wettig, T. & Oefner, P. J. et al.​ (2020) 
  Journal of Computational Biology, 27(3) pp. 386​-389​.​ DOI: https://doi.org/10.1089/cmb.2019.0469 
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• 2020 | Journal Article | Research Paper | 
  ​ ​Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue​
  Reinders, J.; Altenbuchinger, M. ; Limm, K.; Schwarzfischer, P.; Scheidt, T.; Strasser, L. & Richter, J. et al.​ (2020) 
  Scientific Reports, 10(1) pp. 7876​.​ DOI: https://doi.org/10.1038/s41598-020-64212-z 
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• 2019 | Journal Article
  ​ ​A novel lymphoma-associated macrophage interaction signature (LAMIS) provides robust risk prognostication in diffuse large B-cell lymphoma clinical trial cohorts of the DSHNHL​
  Staiger, A. M.; Altenbuchinger, M. ; Ziepert, M.; Kohler, C.; Horn, H.; Huttner, M. & Hüttl, K. S. et al.​ (2019) 
  Leukemia, 34(2) pp. 543​-552​.​ DOI: https://doi.org/10.1038/s41375-019-0573-y 
  ​Details  DOI 

• 2019 | Journal Article | Research Paper | 
  ​ ​Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach​
  Wagner, M.; Hänsel, R.; Reinke, S.; Richter, J.; Altenbuchinger, M. ; Braumann, U.-D. & Spang, R. et al.​ (2019) 
  Biological Procedures Online, 21(1) pp. 13​.​ DOI: https://doi.org/10.1186/s12575-019-0098-9 
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• 2019 | Journal Article | Research Paper
  ​ ​A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease​
  Zacharias, H. U.; Altenbuchinger, M. ; Schultheiss, U. T.; Samol, C.; Kotsis, F.; Poguntke, I. & Sekula, P. et al.​ (2019) 
  Journal of Proteome Research, 18(4) pp. 1796​-1805​.​ DOI: https://doi.org/10.1021/acs.jproteome.8b00983 
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• 2019 | Journal Article | Research Paper | 
  ​ ​A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study​
  Altenbuchinger, M. ; Zacharias, H. U.; Solbrig, S.; Schäfer, A.; Büyüközkan, M.; Schultheiß, U. T. & Kotsis, F. et al.​ (2019) 
  Scientific Reports, 9(1) art. 13954​.​ DOI: https://doi.org/10.1038/s41598-019-50346-2 
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• 2018 | Journal Article
  ​ ​Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2​
  Horn, H.; Kohler, C.; Witzig, R.; Kreuz, M.; Leich, E.; Klapper, W. & Hummel, M. et al.​ (2018) 
  Haematologica, 103(7) pp. 1182​-1190​.​ DOI: https://doi.org/10.3324/haematol.2017.181024 
  ​Details  DOI 

• 2018 | Conference Paper
  ​ ​Loss-Function Learning for Digital Tissue Deconvolution​
  Görtler, F.; Solbrig, S.; Wettig, T.; Oefner, P. J.; Spang, R. & Altenbuchinger, M. ​ (2018)
  In:Raphael, Benjamin J.​ (Ed.), ​Research in Computational Molecular Biology pp. 75​-89. ​22nd Annual International Conference, RECOMB 2018​, Paris.
  Springer. DOI: https://doi.org/10.1007/978-3-319-89929-9_5 
  ​Details  DOI 

• 2018 | Journal Article | Research Paper
  ​ ​Principles of Systems Biology, No. 31​
  Cho, H.; Berger, B.; Peng, J.; Galitzine, C.; Vitek, O.; Beltran, P. M. J. & Cristea, I. M. et al.​ (2018) 
  Cell Systems, 7(2) pp. 133​-135​.​ DOI: https://doi.org/10.1016/j.cels.2018.08.005 
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• 2018 | Journal Article | Research Paper
  ​ ​Round-robin test for the cell-of-origin classification of diffuse large B-cell lymphoma—a feasibility study using full slide staining​
  Reinke, S.; Richter, J.; Fend, F.; Feller, A.; Hansmann, M.-L.; Hüttl, K. & Oschlies, I. et al.​ (2018) 
  Virchows Archiv, 473(3) pp. 341​-349​.​ DOI: https://doi.org/10.1007/s00428-018-2367-4 
  ​Details  DOI 

• 2018 | Journal Article
  ​ ​A New Stromal Signature Applicable to Formalin-Fixed Paraffin-Embedded Tissues Identifies Patients at Risk in Prospective Clinical Trials of the German High-Grade Non-Hodgkin Lymphoma Study Group​
  Staiger, A. M.; Altenbuchinger, M.; Ziepert, M.; Kohler, C.; Horn, H.; Huttner, M. & Huettl, K. et al.​ (2018) 
  Blood, 132(Supplement 1) pp. 343​-343​.​ DOI: https://doi.org/10.1182/blood-2018-99-112450 
  ​Details  DOI 

• 2018 | Journal Article | 
  ​ ​Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression.​
  Feist, M.; Schwarzfischer, P.; Heinrich, P.; Sun, X.; Kemper, J.; von Bonin, F. & Perez-Rubio, P. et al.​ (2018) 
  Nature communications, 9(1) art. 1514​.​ DOI: https://doi.org/10.1038/s41467-018-03803-x 
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• 2017 | Journal Article
  ​ ​Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC​
  Paul, U.; Richter, J.; Stuhlmann-Laiesz, C.; Kreuz, M.; Nagel, I.; Horn, H. & Staiger, A. M. et al.​ (2017) 
  Leukemia & Lymphoma, 59(5) pp. 1213​-1221​.​ DOI: https://doi.org/10.1080/10428194.2017.1365851 
  ​Details  DOI 

• 2017 | Journal Article
  ​ ​Comprehensive Metaboproteomics of Burkitt's and Diffuse Large B-Cell Lymphoma Cell Lines and Primary Tumor Tissues Reveals Distinct Differences in Pyruvate Content and Metabolism​
  Schwarzfischer, P.; Reinders, J.; Dettmer, K.; Kleo, K.; Dimitrova, L.; Hummel, M. & Feist, M. et al.​ (2017) 
  Journal of Proteome Research, 16(3) pp. 1105​-+​.​ DOI: https://doi.org/10.1021/acs.jproteome.6b00164 
  ​Details  DOI  PMID  PMC  WoS 

• 2017 | Journal Article | Research Paper
  ​ ​Cell-of-origin classification by gene expression and MYC-rearrangements in diffuse large B-cell lymphoma of children and adolescents​
  Szczepanowski, M.; Lange, J.; Kohler, C. W.; Masque-Soler, N.; Zimmermann, M.; Aukema, S. M. & Altenbuchinger, M.  et al.​ (2017) 
  British Journal of Haematology, 179(1) pp. 116​-119​.​ DOI: https://doi.org/10.1111/bjh.14812 
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• 2017 | Journal Article | Research Paper
  ​ ​Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints​
  Zacharias, H. U.; Rehberg, T.; Mehrl, S.; Richtmann, D.; Wettig, T.; Oefner, P. J. & Spang, R. et al.​ (2017) 
  Journal of Proteome Research, 16(10) pp. 3596​-3605​.​ DOI: https://doi.org/10.1021/acs.jproteome.7b00325 
  ​Details  DOI  PMID  PMC  arXiv 

• 2017 | Journal Article
  ​ ​External calibration with Drosophila whole-cell spike-ins delivers absolute mRNA fold changes from human RNA-Seq and qPCR data​
  Taruttis, F.; Feist, M.; Schwarzfischer, P.; Gronwald, W.; Kube, D.; Spang, R. & Engelmann, J. C.​ (2017) 
  BioTechniques, 62(2) pp. 53​-61​.​ DOI: https://doi.org/10.2144/000114514 
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• 2017 | Journal Article
  ​ ​Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis​
  Feist, M.; Kemper, J.; Taruttis, F.; Rehberg, T.; Engelmann, J. C.; Gronwald, W. & Hummel, M. et al.​ (2017) 
  International Journal of Cancer, 140(5) pp. 1147​-1158​.​ DOI: https://doi.org/10.1002/ijc.30444 
  ​Details  DOI  PMID  PMC  WoS 

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